Electron-Integrated Controlled Transdermal Drug Delivery - Peb Cov Ntawv Zoo Tshaj Plaws los ntawm Nature-Family Journal

Microneedle arrays sawv cev rau cov txheej txheem kev kho mob me me uas pheej yig tshaj plaws rau kev xa tshuaj tsis muaj mob tsis muaj mob. Microneedles nkag mus rau hauv lub stratum corneum los tsim txoj hauv kev thauj tshuaj thaum zam cov hlab ntsha thiab cov hlab ntsha xaus kom txo qis qhov mob thiab los ntshav. Txog niaj hnub no, kev hloov kho tshuaj lom neeg thiab kev ua kom zoo ntawm lub cev tau txhim kho kev ua tau zoo ntawm microneedle-mediated tshuaj xa.

Txawm li cas los xij, feem ntau cov tshuab microneedle uas twb muaj lawm ua haujlwm nyob rau hauv ib qho kev tso tawm passive, qhov twg cov tshuaj tso tawm yog tswj hwm los ntawm cov khoom siv o lossis tawg. Dynamic thiab meej tuning ntawm kev tswj lub sij hawm thiab ntau npaum li cas tseem nyuaj. Kev sib koom ua ke ntawm microneedle arrays nrog cov tshuab hluav taws xob tswj kom ua tiav kev ua haujlwm, kev xav tau ntawm transdermal kev xa tuaj tau dhau los ua ib qho tseem ceeb hauv lub fwj thiab txoj kev loj hlob loj rau cov khoom siv kho mob microneedle tom ntej.

Kab lus no nthuav tawm peb cov ntaub ntawv cuam tshuam loj tshaj tawm hauvMicrosystems & Nanoengineering(ib phau ntawv Nature). Cov kev tshawb fawb no yog los ntawm pawg tshawb fawb ntawm Prof. Peter B. Lillehoj (Rice University, USA), pab pawg tshawb fawb coj los ntawm Prof. Lelun Jiang (Lub Tsev Kawm Ntawv ntawm Biomedical Engineering, Sun Yat-sen University), thiab Prof. Lingqian Chang pawg (Lub Tsev Kawm Ntawv ntawm Biological Science thiab Medical Engineering, Beihang University). Lawv npog peb cov lus qhia ua ntu zus: ntshav-dawb ceev-kuaj microneedle daim tawv nqaij thaj thaj, smartphone-powered iontophoresis-microneedle array rau tswj transdermal tus me nyuam, thiab micro-nanodevices rau stomatological thiab ophthalmological kuaj thiab kho. Cov haujlwm no muab cov ntaub ntawv muaj txiaj ntsig zoo rau kev kuaj mob microneedle, kev xa tshuaj ntse thiab nthuav dav cov ntawv thov sib txawv.

--- Cov ntaub ntawv zoo heev tsim nyog nyeem ---

01 Microneedle-raws li daim tawv nqaij thaj rau kev kuaj ntshav dawb ceev ceev

Cov kws sau ntawv: Jiang, X., Lillehoj, PBPhau ntawv: Microsyst Nanoeng, 6, 96 (2020) TxuasTau qhov twg los: https://www.nature.com/articles/s41378-020-00206-1 (Images courtesy of the authors)

Txoj kev tshawb no nthuav tawm qhov hollow-microneedle kev sib xyaw ntawm daim tawv nqaij. Hloov chaw ntawm kev sau cov ntshav, cov cuab yeej rho tawm cov kua dej dermal interstitial los ntawm microneedles thiab ua qhov pom pom cov protein-biomarker los ntawm kev sib txuas nrog colloidal-gold lateral-flow test strips. NojPlasmodium falciparumhistidine-nplua nuj protein 2 (PfHRP2, malaria biomarker) raws li cov ntaub ntawv pov thawj-ntawm-lub tswv yim lub hom phiaj, qhov kev ntsuam xyuas ua tiav qhov kev kuaj pom tsis pub dhau 8 ng / mL hauv tsawg dua 20 min yam tsis muaj cov cuab yeej loj. Qhov kev ua haujlwm no ua rau pom thawj zaug ntawm kev sib xyaw ntawm microneedles thiab lateral-flow immunoassay, muab cov tshuaj POCT tshiab tsis muaj ntshav rau cov peev txheej txwv.

02 Smartphone-powered iontophoresis-microneedle array thaj rau tswj transdermal xa

Cov kws sau ntawv: Yang, J., Li, Y., Ye, R.ua al. Phau ntawv: Microsyst Nanoeng, 6, 112 (2020) Txuas: https://www.nature.com/articles/s41378-020-00224-z (Images courtesy of the authors)

Qhov sib txawv ntawm cov pa tso tawm microneedles, qhov haujlwm no tsim ib qho IMAP thaj ua ke nrog cov microneedle arrays nrog iontophoresis. Tsim los ntawm lub xov tooj smartphone, nws siv kev sib koom ua ke "kev nkag mus-diffusion-iontophoresis" tshuaj-kev tswj hwm kev ua haujlwm. Tom qab tho lub stratum corneum, microneedle retract; iontophoresis tsav cov insulin-loaded nanovesicles los ntawm daim tawv nqaij microchannels. Cov tshuaj ntau npaum li cas tuaj yeem tswj tau dynamically los ntawm kev kho hluav taws xob tam sim no siv. Hauv cov qauv-1-mob ntshav qab zib mellitus nas, cov kab ke txhawb nqa normoglycemia ntev thiab txo qis kev pheej hmoo ntawm hypoglycemia piv nrog kev txhaj tshuaj subcutaneous. Qhov kev ua haujlwm no tau lees paub tias kev sib koom ua ke hauv hluav taws xob-microneedle ua rau muaj kev cuam tshuam, ntawm qhov xav tau hloov pauv hloov pauv ntawm macromolecular therapeutics.

03 Micro/nanodevices rau kev soj ntsuam thiab kev kho mob hauv stomatology thiab ophthalmology

Cov kws sau ntawv: Sheng, A., Lin, L., Zhu, J.ua al. (Tus sau sau: Prof. Lingqian Chang)Phau ntawv: Microsyst Nanoeng, 7, 11 (2021) TxuasTau qhov twg los: https://www.nature.com/articles/s41378-021-00238-1

Tsiv dhau qhov kev hloov pauv ntawm daim tawv nqaij, qhov kev tshuaj xyuas no nthuav dav microneedles thiab ntau hom micro-nanodevices rau cov ntaub so ntswg tshwj xeeb rau stomatology thiab ophthalmology. Nws tau sau cov ntaub ntawv tsim tawm, cov qauv tsim qauv thiab kev txiav txim siab txog kev nyab xeeb ntawm micro-nanodevices, npog biochemical sensing los ntawm cellular mus rau cov ntaub so ntswg, nrog rau cov tswv yim kho mob rau lub qhov ncauj mob qog noj ntshav, keratitis, periorbital wrinkles thiab kab mob hauv qhov ncauj. Cov ntsiab lus tseem ceeb ntawm kev tsis sib haum xeeb kuj tau tham txog. Kev tshuaj xyuas hu rau kev sib koom tes sib koom tes ntawm cov kws kho mob thiab cov kws tshawb fawb engineering txhawm rau txhawm rau kho cov kev txhais lus kho mob ntawm micro-nano cov cuab yeej kho mob rau qhov ncauj thiab qhov muag