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Lub Paradigm Hloov los ntawm Cov Cuab Yeej Passive mus rau Kev Txawj Ntse

Cov koob txhaj tshuaj subcutaneous tau raug hloov pauv los ntawm"generic devices"rau"kev daws teeb meem ntawm tus kheej". Cov ntsekoobsystem integrates ntau lub sensors, ua kom lub koob muaj peev xwm paub qhov tseeb. Fiber Bragg grating sensor ntsuas cov koob txhaj tshuaj nrog kev daws teeb meem ntawm 0.1 hli thiab txheeb xyuas cov ntaub so ntswg los ntawm cov qauv strain: cov ntaub so ntswg rog yog maj mam (<100 με), fascia layer strain changes abruptly (200-300 με), and the vascular wall has pulsatile strain. The impedance spectrum sensor applies 10 kHz-1 MHz alternating current at the needle tip and identifies tissues through impedance changes: blood impedance is approximately 150 Ω·cm, muscle is approximately 300 Ω·cm, and fat is approximately 2000 Ω·cm. The temperature sensor has an accuracy of ±0.1℃ and can detect an inflammatory temperature rise of 0.5℃. After the data from these sensors are fused, a real-time tissue map of the puncture path can be constructed.

Lub Painless Technology Breakthroughs

Kev siv tshuab tsis mob tau ua rau muaj kev cuam tshuam hauv ntau yam. Cov cuab yeej vibration analgesic integrates micro piezoelectric ceramics, tsim micro vibrations nrog zaus ntawm 100-150 Hz thiab amplitude ntawm 0.05-0.1 hli. Cov kev vibrations no inhibit qhov mob kis tau los ntawm kev nkag mus rau txoj kev xav. Kev sim tshuaj ntsuam xyuas tau pom tias VAS qhov mob ntawm pawg kev vibration txo qis los ntawm 3.2 ± 1.1 ntawm pawg tswj mus rau 1.5 ± 0.8 (p <0.01). Kev kho kub ua ntej ua kom sov lub koob mus rau 34 degree, tshem tawm qhov kub thiab txias sib txawv ntawm daim tawv nqaij (feem ntau yog 8-10 degree) thiab tsis txhob ua kom cov kub receptors. Kev kho cov tshuaj loog ua ntej tsuas yog siv sijhawm 15 vib nas this: cov koob taub dips mus rau hauv microcapsules ntawm cov tshuaj loog hauv zos (particle loj 5-10 μm), tso tawm tam sim ntawd thaum nkag rau hauv daim tawv nqaij, thiab siv sijhawm 2-3 vib nas this. Pulsed electric teb tsim ib qho hluav taws xob teb ntawm rab koob ntxig rau pem hauv ntej, hloov pauv lub peev xwm ntawm cov paj hlwb thiab thaiv cov teeb liab xa mus rau 0.5-1 thib ob, txaus los ua kom tiav qhov puncture.

Txoj Kev Hloov Khoom Tshiab

Cov khoom siv hloov pauv tshiab tab tom pib. Biodegradable magnesium alloy koob (WE43 series) tag nrho degrade hauv lub cev tsis pub dhau 3 mus rau 6 lub hlis, nrog rau cov khoom degradation yog magnesium ions thiab hydrogen gas. Tus qub txhawb cov pob txha kho, thaum tom kawg tuaj yeem nqus tau. Daim duab- nco txog cov koob tshuaj polymer khoov ntawm lub cev kub, tso cai rau lawv hla kev cuam tshuam thiab ncav cuag lub hom phiaj. Tom qab ntawd, lawv rov qab mus rau lub xeev ncaj nraim kom yooj yim tshem tawm. Cov koob tshuaj ua kua (gallium-raws li alloy) nyob rau hauv cov kua hauv lub xeev ntawm chav tsev kub thiab khov kho tom qab txhaj tshuaj thiab tuaj yeem siv rau kev kho mob embolization. Qhov siab tshaj plaws yog bio-hybrid koob: cov hlwb los ntawm tus neeg mob tau cog rau ntawm qhov chaw ntawm biodegradable koob los ua ib qho kev cuam tshuam, txo cov kev xav txawv teb chaws lub cev. Tus kheej- koob kho mob tso tawm cov tshuaj kho ntawm micro- tawg, ua rau lawv lub neej ntev li 5 txog 10 npaug.

Micro-Nano Manufacturing Technology

Micro-nano manufacturing technology tsim cov ntaub ntawv tshiab. Lub micro- koob array yog ib qho kev cuam tshuam kev tsim: 100 txog 1,000 micro- koob nrog qhov ntev ntawm 200 mus rau 800 μm yog teem rau ntawm 1 cm² substrate, nkag mus rau lub stratum corneum tab sis tsis pub tshaj lub dermal txheej uas qhov mob nyob {10}. Sab hauv txoj kab uas hla ntawm hollow micro- koob yog 10 mus rau 50 μm, ua kom muaj kev sib txuas ntxiv; cov khoom micro- koob yog coated nrog tshuaj, uas yaj nyob rau hauv lub stratum corneum; lub coated micro- koob muaj nws qhov chaw ntim nrog cov tshuaj, uas tau tso tawm tom qab tso tawm . 3D luam ntawv ua rau tus kheej: cov koob nkhaus luam tawm raws li tus neeg mob cov ntaub ntawv MRI tuaj yeem ncav cuag cov ntsiab lus uas cov koob ncaj ncaj tsis tuaj yeem ncav cuag. Plaub-dimensional printing yog ntse dua: lub koob zoo hloov nyob rau hauv lub cev kub los yog ib tug tshwj xeeb pH, xws li unfolding barbs thaum nkag mus rau lub qog microenvironment (pH 6.5 - 7.0) los tiv thaiv detachment.

Integrated Precise Drug Delivery System

Lub kaw - lub voj kaw tsis tu ncua saib xyuas cov ntshav qab zib thiab cia li txhaj tshuaj insulin, nce tus nqi ntawm kev ua tiav cov hom phiaj ntawm glycosylated hemoglobin los ntawm 30% hauv kev kho mob ib txwm mus rau 70%. Lub hom phiaj kev xa khoom sib xyaw ua ke sib nqus- cov ntaub ntawv teb ntawm rab koob thiab sib sau ua ke ntawm lub hom phiaj cov ntaub so ntswg raws li kev taw qhia ntawm sab nraud magnetic teb, ua rau cov tshuaj hauv zos concentration ntawm 10 mus rau 100 zaug. Lub tshuab pulse tso tawm cov tshuaj raws li qhov xav tau los ntawm lub sijhawm yaj ntawm theem- hloov cov khoom siv los ntawm micro- cov khoom cua sov. Qhov kev txawj ntse tshaj plaws yog qhov"sensing{0}}kev txiav txim siab-execution"Kev sib xyaw ua ke: tsis tu ncua saib xyuas ntau yam biomarkers, suav cov phiaj xwm kev xa tshuaj zoo tshaj plaws los ntawm algorithms, thiab ua tiav qhov kev txhaj tshuaj, nce kev kho mob ntev los ntawm"Standardized Plan"rau"Personalized dynamic hloov kho".

Cov kev siv thev naus laus zis no tau hloov cov koob txhaj tshuaj subcutaneous los ntawm cov cuab yeej siv tshuab yooj yim mus rau hauv cov chaw kho mob ntse, qhib cov qauv kho tshiab hauv thaj chaw xws li kev tswj ntshav qab zib, kev kho qog, kev tiv thaiv kab mob, thiab kab mob hauv lub paj hlwb. Lawv sawv cev rau yav tom ntej kev taw qhia ntawm kev sib sib zog nqus ntawm cov cuab yeej kho mob nrog biotechnology, cov ntaub ntawv thev naus laus zis, thiab cov ntaub ntawv tshawb fawb.