Lub Micro-Kev hloov pauv ntawm Puncture Interface: Yuav ua li cas cov ntaub ntawv txheej tau hloov pauv qhov kev txhaj tshuaj thiab cov ntaub so ntswg teb

Lub Micro-Kev hloov pauv ntawm Puncture Interface: Yuav ua li cas cov ntaub ntawv txheej tau hloov kho qhov kev txhaj tshuaj thiab cov ntaub so ntswg teb

Ntsiab lus:​ Ultra-lubricious hydrophilic txheej koob + Ua tiav qhov tsis hnov ​​​​tsw thiab txo cov ntaub so ntswg

Ntawm qhov sib cuam tshuam ntawm kev txhaj tshuaj subcutaneous-kev sib cuam tshuam kev kho mob feem ntau- mob thiab cov ntaub so ntswg puas tsuaj tsis yog los ntawm cov khoom lag luam, tab sis cov kev hloov pauv uas tuaj yeem tswj hwm los ntawm cov ntaub ntawv tshawb fawb. Qhov tam sim ntawd tus koob taub pierces ntawm daim tawv nqaij, lub microscopic battlefield tshwm sim qhov twg mechanical rog, nto chemistry, thiab cov ntaub so ntswg lom koom nyob rau hauv complex kev sib tshuam. Los ntawm kev polishing du ntawm cov hlau tsis huv, mus rau silicone coatings, thiab tam sim no mus rau tiam tshiab ntawm ultra-hydrophilic polymer txheej, txhua qhov kev hloov pauv hauv rab koob nto kho tshuab lub hom phiaj los hloov puncture los ntawm "kev raug mob" rau hauv "kev hloov." Lub hom phiaj tseem ceeb yog txhawm rau txo qis qhov pom qhov mob thiab cov lus teb ntawm lub cev inflammatory hauv tib neeg lub cev, thaum ua kom cov khoom xa tuaj.

Lub "Lubrication" Logic ntawm Silicone Coatings thiab Lawv Achilles 'Heel

Tau ntev, kev kho mob - qib silicone roj yog cov txheej txheem kev daws teeb meem rau kev txo qhov tsis haum. Nws lub hauv paus ntsiab lus suav nrog kev tsim cov yeeb yaj kiab hydrophobic lubricating zaj duab xis ntawm stainless hlau koob nto, hloov qhov kev sib txhuam qhuav ntawm rab koob thiab cov ntaub so ntswg rau hauv ciam lubrication, uas feem ntau txo qhov quab yuam los ntawm 20% -30%. Txawm li cas los xij, cov kev txwv ntawm silicone tau dhau los ua pom tseeb nrog kev siv tob dua. Ua ntej, silicone roj microdroplets tuaj yeem nkag mus rau hauv cov ntaub so ntswg thaum txhaj tshuaj, uas tuaj yeem ua rau muaj kev cuam tshuam qeeb qeeb xws li lub cev txawv teb chaws granulomas-ib qho tshwm sim qhia hauv cov neeg mob ntshav qab zib ntau ntau. Qhov thib ob, cov txheej silicone yuav raug ntxuav ib nrab ntawm kev sib cuag nrog cov ntshav los yog cov ntaub so ntswg, ua rau lubrication efficiency degrade lub sij hawm. Qhov tseem ceeb tshaj plaws, cov roj silicone tuaj yeem raug tsis yog - tshwj xeeb adsorption nrog qee cov tshuaj lom neeg (tshwj xeeb tshaj yog monoclonal antibodies thiab peptide cov tshuaj hormones), ua rau poob tshuaj thiab noj tsis raug. Rau qhov kim thiab meej hom kev kho mob, qhov no yog qhov ua rau tuag taus.

Lub "Interface Fusion" Philosophy ntawm Ultra-Hydrophilic Txheej

Lub tswv yim tsim qauv ntawm cov txheej txheem tshiab ntawm cov txheej txheem tau dhau los ua qhov hloov pauv tseem ceeb: los ntawm "kev cais tawm" cov ntaub so ntswg mus rau "ua raws" nrog nws. Ultra- hydrophilic coatings raws li Polyvinylpyrrolidone (PVP), Polyethylene Glycol (PEG), los yog Hyaluronic Acid nyob twj ywm indistinguishable los ntawm zoo tib yam koob nyob rau hauv lawv qhuav lub xeev. Thaum lawv hu rau cov ntaub so ntswg los yog cov tshuaj txhaj tshuaj prefilled, txheej hydrates thiab swells sai nyob rau hauv ib feem kaum ntawm ib tug thib ob, tsim ib tug gel-zoo li lubricating txheej nrog ib tug dej ntsiab lus ntau tshaj 90%. Cov txheej hydrogel no ua tiav ntau yam kev sib tw:

Tsis tshua muaj kev sib txhuam coefficient, txo qis rau qis dua 0.01, txo qis zog ntxiv los ntawm 40% -50% piv rau silicone-cov koob coated, thiab txo qhov Visual Analogue Scale (VAS) qhov mob tau los ntawm qhov nruab nrab ntawm 1.5 cov ntsiab lus.

Biocompatibility zoo heev: Hydrogel Cheebtsam yog metabolizable los yog absorbable los ntawm tib neeg lub cev, ua rau tsis muaj residue txaus ntshai.

Tshuaj-kev phooj ywg: Lawv cov tshuaj inertness tsis txhob cuam tshuam nrog cov protein-raws li cov tshuaj, ua kom ntseeg tau 100% ntawm cov tshuaj noj.

Intelligent Advancement ntawm "Lubrication-Kev Kho Mob" Integrated Coatings

Txiav- kev tshawb fawb ntug yog kho dua cov txheej txheem los ntawm cov roj lubrication mus rau lub platform ua haujlwm. Piv txwv li, heparin- cov coatings coatings inhibit microthrombus tsim nyob rau hauv lub koob ib puag ncig thaum muab lubrication. Rau cov neeg mob uas xav tau ntev - txhaj tshuaj anticoagulant, qhov no tuaj yeem txo qhov nqaij tawv nqaij. Sustained - tso tawm cov tshuaj loog hauv zos cov tshuaj pleev ib ce covalently khi Lidocaine los yog Prilocaine molecules rau polymer chains, tso lawv maj mam nyob ib ncig ntawm rab koob thaum lub sij hawm puncture kom tiav tam sim ntawd "mob txhaj." Qhov no yog qhov tshwj xeeb tshaj yog rau kev txhaj tshuaj tiv thaiv menyuam yaus thiab insulin-cov neeg mob ntshav qab zib uas xav tau txhaj tshuaj ntau zaus. Qhov kev hloov pauv loj tshaj plaws yog hemostatic/anti-inflammatory dual{11}} txheej txheej ua haujlwm: nws txheej sab hauv muaj cov khoom siv pro-coagulant (xws li, Chitosan) txhawm rau kaw cov hlab ntsha sai sai, thaum txheej txheej sab nrauv muaj cov tshuaj tiv thaiv kab mob (xws li Dexamethasone). Qhov no tuaj yeem txo qhov tshwm sim tom qab{19}} txhaj tshuaj hauv zos redness, o, thiab induration ntau dua 70%.

Nanometer{0}}Level Precision nyob rau hauv txheej txheej txheej txiav txim siab ua tiav

Uniformity, khi lub zog, thiab thickness yog cov txheej txheem tseem ceeb rau txheej txheej. Cov thev naus laus zis xws li Atomic Layer Deposition (ALD) lossis pib tshuaj Vapor Deposition (iCVD) pab kom tsim cov yeeb yaj kiab polymer tsuas yog kaum tawm nanometers tuab ntawm ob sab hauv thiab sab nrauv ntawm lub cev koob, nrog lub zog sib txuas muaj peev xwm tiv taus qhov siab ntawm cov koob txhaj tshuaj thiab siab - nrawm nrawm. Rau qhov tseem ceeb ntawm rab koob taub hau bevel, cheeb tsam - kev hloov kho kom ntseeg tau tias cov khoom siv lubricating npog lub ntug txiav kom meej yam tsis tas yuav qhwv lub taub thiab cuam tshuam qhov ntse. Cov txheej txheem tshuaj xyuas hauv online Advanced (xws li laser confocal microscopy) tso cai rau 100% tag nrho cov kev soj ntsuam ntawm txheej thickness thiab uniformity rau txhua batch.

Kaw lub voj los ntawm kev soj ntsuam cov lus teb rau cov pov thawj-Raws li cov ntaub ntawv

Tus nqi ntawm cov coatings yog qhov kawg txhais los ntawm cov ntaub ntawv kho mob. Loj -scale Randomized Controlled Trials (RCTs) qhia tias ntawm cov neeg mob ntshav qab zib hom 2 uas siv ultra-hydrophilic coated insulin cwj mem koob, qhov feem pua ​​​​ntawm kev kho tsis zoo los ntawm kev txhaj tshuaj poob qis los ntawm 28% mus rau 9%. Hauv cov chaw kho mob menyuam yaus, kev siv cov koob txhaj tshuaj nrog cov tshuaj loog ua kom txo tau lub sij hawm quaj thiab kev siv zog ntawm cov menyuam yaus, ua tiav cov niam txiv txaus siab txog li 96%. Los ntawm kev xav txog kev noj qab haus huv kev lag luam, txo cov teeb meem thiab kev tuav cov nqi uas tshwm sim los ntawm kev txhaj tshuaj thiab cov nodules ua rau cov koob nrog cov txheej txheem zoo tshaj plaws ntawm tag nrho - cov nqi kho mob, txawm tias tus nqi siab dua me ntsis.

Nyob rau hauv lub neej yav tom ntej, txheej txheej technology yuav hloov mus rau "sensing thiab teb." Cov txheej txheem ntse yuav hloov kho lawv cov khoom siv lubricating lossis tso cov tshuaj tshwj xeeb raws li cov ntaub so ntswg tiv tauj (subcutaneous rog, nqaij, cov hlab ntsha). Biodegradable fluorescent coatings yuav ua rau cov koob txhaj tshuaj pom nyob rau hauv lub teeb tshwj xeeb tsis ntev tom qab txhaj tshuaj, pab txhawb kev sib hloov ntawm qhov chaw txhaj tshuaj los ntawm cov neeg ua haujlwm tu neeg mob. Los ntawm cov khoom siv tshiab, kev txhaj tshuaj subcutaneous - cov txheej txheem kho mob yooj yim tshaj plaws - yog txuas ntxiv mus rau lub xeev zoo tshaj plaws ntawm "kev tsis pom kev, tsis muaj mob, thiab kev ua haujlwm," tsis tu ncua txhim kho kev kho mob thiab kev nyab xeeb margins rau ntau lab tus neeg mob ntawm lub ntsuas ntsuas.