Kev Kho Mob Tus Nqi Ntawm Microneedle Therapy hauv Kev Kho Mob Thiab Cov Hniav Rov Qab

https://en.wikipedia.org/wiki/Microneedles

Thaum pej xeem sib thammicroneedlekev kho mob, lub ntsej muag rejuvenation thiab qhov chaw -lightening feem ntau yog thawj daim ntawv thov uas los rau hauv siab. Txawm li cas los xij, hauv cov tshuaj loj, microneedles tau ua lub luag haujlwm tseem ceeb tshaj li qhov "kev zoo nkauj" -lawv muab cov kev daws teeb meem tshiab rau kev kho qhov txhab thiab cov ntaub so ntswg, nrog rau kev kho mob thiab kev sib raug zoo tseem ceeb uas tsis tuaj yeem saib tsis tau.

Cov qhov txhab mob ntev sawv cev rau qhov tsis txaus ntseeg txog kev noj qab haus huv thoob ntiaj teb. Mob ntshav qab zib ko taw rwj, mob siab, thiab venous ceg ulcers cuam tshuam txog kwv yees li 40 lab tus neeg mob thoob ntiaj teb, ua rau muaj nqi kho mob txhua xyoo ntau dua $ 10 billion. Cov qhov txhab no muaj qhov zoo sib xws: lawv stagnate nyob rau hauv lub inflammatory theem, yam ntxwv los ntawm ib tug tsis txaus ntawm cov hlab ntsha tshiab thiab tsis txaus loj hlob ntau concentrations. Kev sib tsoo tsoos yields txwv cov txiaj ntsig, thaum kim bioactive dressings nyuaj rau nrov. Microneedle therapy qhia tau hais tias qhov tshwj xeeb dual qhov zoo ntawm no: kev sib koom ua ke ntawm lub cev stimulation thiab kev xa tshuaj.

Nyob rau theem ntawm lub cev, cov microchannels tsim los ntawm microneedle arrays qhib cov platelets kom tso Platelet-Derived Growth Factor (PDGF) thiab Transforming Growth Factor-beta (TGF- ). Cov kab mob endogenous signaling molecules nrhiav fibroblasts thiab macrophages los pib txheej txheem kho. Nyob rau tib lub sijhawm, kev tswj hwm micro- raug mob ua rau cov lus teb aseptic inflammatory hauv zos, paradoxically pab txhawm rau txhawm rau "kho qhov tsis zoo." Cov kev sim ntawm cov kab mob ntshav qab zib nas cov qauv qhia tau hais tias kho qhov txhab nkaus xwb nrog cov microneedle dawb lias ua kom kho tau li ntawm 35% piv rau kev tswj hwm.

Ntawm kev xa tshuaj rau pem hauv ntej, microneedles tuaj yeem xa cov pro- kho cov proteins, xws li Vascular Endothelial Growth Factor (VEGF) thiab Epidermal Growth Factor (EGF), tob rau hauv lub qhov txhab. Siv tshuaj pleev ib ce, cov macromolecules yuav sai sai degraded los ntawm proteases nyob rau hauv qhov txhab exudate; microneedles hla qhov no los ntawm kev xa lawv ncaj qha mus rau hauv cov ntaub so ntswg. Cov kev tshawb fawb soj ntsuam pom tau tias VEGF-loaded thaj ua rau thaj rau cov mob ntshav qab zib ko taw tau ua tiav 72% kaw tus nqi tsis pub dhau 12 lub lis piam, piv rau tsuas yog 44% hauv pawg saib xyuas tus qauv.

Hauv kev tswj cov caws pliav, microneedles ua tau zoo ntawm kev kho cov kab mob hypertrophic thiab keloids, uas nws cov kab mob tseem ceeb cuam tshuam nrog kev loj hlob ntawm fibroblast ntau dhau thiab tsis zoo li collagen deposition. Los ntawm lub cev cuam tshuam cov kab mob collagen tsis zoo thaum xa cov tshuaj tiv thaiv -fibrotic xws li Triamcinolone lossis 5-Fluorouracil, microneedles ua tiav cov txiaj ntsig kho mob ntawm "tawg qub los tsim cov tshiab." Cov neeg mob feem ntau xav tau tsuas yog 3 mus rau 5 zaug rau qhov caws pliav tuab kom txo qis dua 50%, nrog rau cov nqi rov qab qis dua li cov tshuaj txhaj tshuaj ib leeg.

Rau cov plaub hau poob-ib yam mob cuam tshuam rau ntau pua lab- txoj kev kho microneedle qhib qhov tsis yog -pharmacological path. Stimulation ua rau kom cov ntshav ntws hauv zos thiab ua kom cov qia hlwb nyob ib ncig ntawm cov hauv paus hniav. Ua ke nrog Platelet-Nrog Plasma (PRP) lossis Minoxidil, cov plaub hau dav dav tuaj yeem nce li 20 mus rau 30 plaub hau ib square centimeter hauv rau lub hlis. Los ntawm qhov txhab mus rau caws pliav, los ntawm daim tawv nqaij mus rau cov plaub hau, kev kho mob microneedle ua pov thawj tias nws yog ntau tshaj li cov cuab yeej kho kom zoo nkauj - nws yog ib qho tseem ceeb qhib lub qhov rooj rau cov tshuaj regenerative.