Tus Qauv Kub hauv Hematologic Oncology: Daim Ntawv Thov Ntawm Cov Pob Txha Pob Txha Biopsy Koob hauv Cov Kab Mob Hematological

https://www.chamfondbiotech.com/4-types-of-pob txha-marrow-biopsy-needles/

Nyob rau hauv kev kuaj mob thiab kev kho mob ntawm cov kab mob hematological, kev kuaj mob meej yog qhov tsim nyog rau kev tsim cov tswv yim kho mob zoo. Cov pob txha pob txha biopsy koob, raws li cov cuab yeej tseem ceeb rau kev tau txais cov pob txha pob txha cov ntaub so ntswg, ua lub luag haujlwm tsis tuaj yeem hloov pauv hauv kev kuaj mob thiab kev ua haujlwm ntawm cov kab mob malignant hematological, ua tau raws li txoj cai."Gold Standard"nyob rau hauv hematologic oncology.

I. Leukemia Diagnosis

Kev kuaj mob ntawm leukemia- suav nrog Mob Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Chronic Myeloid Leukemia (CML), thiab Chronic Lymphocytic Leukemia (CLL)-hinges ntawm kev tshuaj xyuas dav dav ntawm cov pob txha pob txha morphology, thiab cov kab mob sib kis, Siv cov pob txha pob txha biopsy koob, cov kws kho mob tau txais ob qho tib si kua pob txha thiab cov ntaub so ntswg tseem ceeb, ua kom pom qhov pom tseeb ntawm cov feem pua ​​​​ntawm cov pob txha, kev sib txawv ntawm tes, thiab muaj cov chromosomal txawv txav (xws li, Philadelphia chromosome). Piv txwv li, hauv kev kuaj mobMob Promyelocytic Leukemia (APL)Kev kuaj mob biopsy qhia pom tias muaj qhov txawv txav ntawm cov promyelocytes, thaum tom qab kev tshuaj ntsuam molecular qhia tiasPML-RAR fusion noob, coj ncaj qha kev kho mob nrog tag nrho cov -trans retinoic acid (ATRA) thiab arsenic trioxide.

II. Lymphoma Staging thiab ntsuam xyuas ntawm pob txha pob txha

Lymphoma, ib qho mob qog noj ntshav uas tshwm sim hauv cov kab mob lymphatic, tso siab ntau rau ntawm pob txha pob txha biopsy rau theem thiab kev npaj kho mob. Txawm hais tias tus kab mob cuam tshuam nrog cov pob txha pob txha yog qhov tseem ceeb ntawm kev txiav txim siabAnn Arbor Stage-tshwj xeeb txhais cov kab mob Theem IV. Cov kws kho mob siv rab koob biopsy los sau cov pob txha pob txha thiab cov ntshav los ntawm qhov chaw xws li posterior iliac crest. Kev txheeb xyuas qhov txawv txav lymphoid aggregates lossis tsim ntawmlymphomatous nodulesnyob rau hauv lub core specimen paub meej tias pob txha pob txha koom tes. Qhov kev tshawb pom no qhia txog kab mob siab heev, yuav tsum tau siv tshuaj kho mob hnyav thiab muaj peev xwm hematopoietic qia cell transplantation. Nyob rau hauv txhoj puab heev malignancies zoo liDiffuse Loj B-Cell Lymphoma (DLBCL), cov txiaj ntsig biopsy ncaj qha qhia ob qho tib si kev soj ntsuam thiab kev xaiv ntawm kev siv tshuaj kho mob.

III. Kev kuaj mob ntawm Myelodysplastic Syndromes (MDS)

Kev kuaj mob ntawmMyelodysplastic Syndrome (MDS)-ib pawg neeg heterogeneous ntawm clonal hematopoietic stem cell mob tshwm sim los ntawm kev ua tsis tau zoo hematopoiesis thiab peripheral cytopenias- kuj tseem nyob ntawm qhov koob tshuaj biopsy. Piv nrog rau qhov yooj yim aspiration, lub hauv paus biopsy muab cov ntaub ntawv nplua nuj ntau: nws tso cai rau kev ntsuam xyuas meej ntawmmob plab cellularity (hyper-/hypo-cellularity), covdegree ntawm fibrosis, covtawg feem pua, thiab lub xub ntiag ntawmAbnormal Localization of Immature Precursors (ALIP). Cov kev txwv no yog kev txiav txim siab rau kev sib txawv ntawm MDS subtypes (piv txwv li, MDS nrog ib leeg -lineage dysplasia, MDS nrog lub nplhaib sideroblasts) thiab tsis suav nrog lwm yam kev mob cytopenic xws li aplastic anemia.

Xaus

Los ntawm qhov tseeb subtyping ntawm leukemia thiab cov txheej txheem ntawm lymphoma mus rau complex diagnostic algorithms ntawm MDS, cov pob txha pob txha biopsy koob muab cov ntaub ntawv pov thawj tshaj plaws thiab ncaj qha rau kev txiav txim siab kho mob- ua los ntawm nws lub peev xwm kom tau txais cov ntaub so ntswg tsis zoo. Nws yog ntau tshaj li ib qho kev kuaj mob xwb; nws ua tus choj tseem ceeb txuas rau kev tshawb fawb hauv chaw soj nstuam rau kev kho mob, txhawb kev tswj hwm ntawm hematologic malignancies mus rau lub sijhawm ib txwm muaj - nce precision.