Kev Tso Tawm Ntawm Kev Ua Tau Zoo

Peb officially launched lubbulk-hloov ultra-slippery ntotechnology rau Chiba koob. Ua txhaum qhov kev txwv ntawm kev hnav yooj yim ntawm cov pa coatings, cov thev naus laus zis no embeds qis-nto-zog cov khoom siv rau hauv rab koob nto ntawm atomic-level bonding siv plasma immersion ion implantation thiab deposition (PIIID), tsim cov pob zeb diamond-zoo li carbon-based ultra-nplaum txheej txheej sib xyaw nrog seamlessly. los ntawm ntau dua 70%, thaum featuring mus tas li hydrophilicity, zoo heev anti-protein-adhesion thiab antithrombotic zog. Nws yog ib tug leap ntawm lub cev smoothness mus rau lom inertness, teem ib tug tshiab tus qauv rau rov puncture thiab mus sij hawm ntev indwelling daim ntaub ntawv.

R&D keeb kwm yav dhau thiab cov ntsiab lus tseem ceeb mob

Kev sib txhuam ntawm Chiba koob thiab cov ntaub so ntswg thaum lub sij hawm puncture yog ib qho ntawm cov tseem ceeb ua rau mob, nqaij raug mob, koob-txoj kab los ntshav thiab txawm koob tip blockage. Txawm tias tom qab polishing, cov pa stainless-steel nto muaj inherently siab nto zog, ua rau kom ceev ceev adhesion ntawm cov nqaijrog proteins thiab biofilm tsim, uas ua rau kom cov puncture kuj. Thaum siv rau vascular puncture los yog indwelling, liab qab hlau nto ua hauj lwm hotbeds rau thrombosis.Common polymer coatings xws li PTFE siv los ntawm txau los yog dip-txheej txheej raug kev txom nyem los ntawm tsis muaj zog bonding quab yuam thiab yuav tev tawm thaum dhau los ntawm cov ntaub so ntswg tawv los yog tom qab rov siv dua, nrog tev fragments ua rau muaj kev pheej hmoo ntawm txawv teb chaws-lub cev cov tshuaj tiv thaiv nyob rau hauv vivo. Kev ua lag luam urgently xav tau ib qho kev daws teeb meem uas yog ob qho tib si mus tas li slippery thiab ruaj khov kiag li.

Core Technological Innovations

Peb cov thev naus laus zis tseem ceeb tsim kom muaj qhov sib xyaw ua ke los ntawm kev hloov pauv ntau:

• Plasma Immersion Ion Implantation thiab Deposition (PIID)Cov koob Chiba tau muab tso rau hauv cov ntshav plasma siab hauv lub tshuab nqus tsev. High-zog ion bombardment (ion implantation) ua ntej tsav cov ntsiab lus xws li carbon thiab silicon kaum ntawm nanometers hauv qab stainless-steel nto los tsim ib qho kev hloov pauv ntxiv. Tom qab ntawd, silicon- thiab oxygen-muaj precursor gases tau nkag mus rau hauv plasma ib puag ncig rau tshuaj vapor deposition (CVD) ntawm lub koob nto, loj hlob ib tug amorphous network-structured txheej nplua nuj nyob rau hauv Si-O-C bonds. Cov txheej no txuas rau lub substrate los ntawm atomic diffusion thiab chemical bonding es tsis yog lub cev txuas, xa cov kev sib txuas siab heev.
• Kev them nyiaj yug ntawm Ultra-Slippery thiab Hydrophilic PropertiesLos ntawm kev tswj hwm cov kev txwv tsis pub tso tseg, cov txheej txheem tshuaj lom neeg sab nraud yog enriched nrog hydrophilic pawg xws li hydroxyl pawg. Thaum sib cuag nrog cov ntshav los yog cov ntaub so ntswg, qhov chaw tam sim ntawd attracts dej molecules los ua ib tug robust hydrated molecular txheej. Cov yeeb yaj kiab ua kua dej no ua lub luag haujlwm zoo tshaj plaws ntawm cov koob thiab cov ntaub so ntswg, ua tiav cov dej-lubrication nyhuv. Meanwhile, deg tshuaj inertness tiv thaiv ruaj adhesion ntawm protein molecules los ntawm hydrophobic los yog electrostatic kev sib tshuam, fundamentally inhibiting biofilm tsim.
• Comprehensive Performance EnhancementCov txheej txheem hloov kho nta pob zeb diamond zoo li cov khoom siv nrog ultra-siab microhardness thiab tshaj tsib npaug ntawm kev hnav tsis kam ntawm cov pa stainless hlau, yooj yim zam kev sib tsoo ntawm cov pob txha. Nws kuj nthuav tawm cov tshuaj lom neeg ruaj khov zoo heev, tiv thaiv txhua yam tshuaj tua kab mob thiab ua kom tsis muaj menyuam yam tsis muaj kev ua haujlwm degradation.

Mechanisms ntawm Action

Nws cov txheej txheem tseem ceeb nyob rau hauv kev tsim lub zoo meej interface nrog tsawg nto zog, siab hardness thiab tshuaj inertness. Cov txheej txheem hloov pauv tau tsim los ntawm ion implantation muab cov khoom siv ntxiv-pob zeb-style kev sib txuas ntawm cov txheej txheem hloov kho thiab cov hlau substrate, tshem tawm cov kev pheej hmoo ntawm tev. Hydrophilic nto chemical yam ntxwv ceev ceev kaw dej molecules ntawm hydrogen bonds los tsim ib tug ruaj khov hydrated txheej. Thaum lub sij hawm puncture, lub koob swb tawm tsam cov yeeb yaj kiab dej no ntau dua li cov ntaub so ntswg qhuav, txo qis kev sib txhuam.Cov yeeb yaj kiab dej no kuj ua rau lub cev cais cov platelets thiab coagulation yam hauv cov ntshav los ntawm cov hlau qhov chaw, ua rau qeeb pib ntawm coagulation cascade. Cov tshuaj lom neeg inertness thiab du morphology hinder irreversible conformational kev hloov thiab adhesion ntawm protein molecules (xws li, fibrinogen, albumin), inhibiting tsim ntawm thrombotic cores thiab biofilms ntawm molecular qib.

Kev txheeb xyuas qhov ua tau zoo

Kev ntsuam xyuas kev sib txhuam coefficient qhia tias qhov kev sib txhuam tsis sib haum xeeb ntawm kev kho Chiba koob hauv cov ntaub so ntswg-simulating media yog qis dua 0.1, qis dua 0.35 rau cov koob tsis kho. Hauv cov qauv kev ntsuas hauv vitro thrombosis, thrombus adhesion hnyav ntawm qhov chaw hloov kho tau txo qis dua 90%. Protein adhesion tests siv fluorescent-labeled fibrinogen qhia qhov adhesion tsuas yog 5% ntawm pawg tswj. Nyob rau hauv cov tsiaj vascular indwelling qauv, qhov pib ntawm mob thrombosis tshwm sim los ntawm kev hloov cov koob yog qeeb qeeb. Kev kho mob tawm tswv yim tshwj xeeb tshaj yog intuitive: radiologists qhia tias ultra-slippery Chiba koob xa exceptionally du manipulation nyob rau hauv cov txheej txheem xws li percutaneous transhepatic cholangiodrainage, nrog ze li ntawm imperceptible siab, thiab imperceptible penetration. Cov txheej txheem microvascular, thiab qhov txo qis hauv cov kab mob ntshav qab zib kab mob ntshav qab zib.

R & D Strategy thiab Philosophy

Peb tuav lub hauv paus philosophy:Nto sib npaug ua haujlwm.Rau cov khoom siv cuam tshuam, qhov saum npoo yog tib qho kev cuam tshuam nrog kev ua neej nyob, nws lub zog txiav txim siab qhov kawg ntawm biosafety ntawm cov cuab yeej.Our R & D lub tswv yim txav dhau qhov yooj yim mechanical polishing rau delve rau hauv plasma physics thiab nto chemistry, proactively tsim thiab tsim lub hom phiaj interfacial zog. Peb nrhiav kev hloov kho dua li tsuas yog txheej txheej, ua kom muaj cov khoom siv tshuaj lom neeg tshiab pib los ntawm ntau tshaj kaum ntawm nanometers ntawm cov ntaub ntawv.

Yav tom ntej Outlook

Nyob rau hauv lub neej yav tom ntej, peb yuav tsim cov ntse teb thiab kho qhov chaw. Cov lus qhia tshawb fawb suav nrog pH- lossis enzyme-tej chaw uas tso tawm cov tshuaj tua kab mob hauv cov kua qaub lossis cov enzymes tshwj xeeb ntawm cov kab mob; heparin- lossis nitric-oxide-dawb-dawb-loaded qhov chaw ua kom tswj tau cov tshuaj tiv thaiv kev tso tawm rau cov catheters hauv tsev mus sij hawm ntev los tiv thaiv kev kis kab mob thiab thrombosis; thiab antifouling nto nrog active bacteria-repellent functions.Peb lub hom phiaj yog los hloov qhov chaw ntawm Chiba koob thiab muab tau cov kev cuam tshuam cov cuab yeej los ntawm passive lub cev teeb meem mus rau hauv ntse lom interfaces uas teb rau physiological hloov, nquag koom nyob rau hauv kev kho mob thiab tswj lub cev homeostasis.