Cov Khoom Siv Evolution Thiab Technological Breakthrough: Txoj Kev Taug Kev Los Ntawm Cov Hlau Stainless Mus Rau Kev Txawj Ntse Polymers

Cov Khoom Siv Evolution thiab Technological Breakthrough: Cov Kev Tsim Nyog Taug Kev los ntawm Stainless Hlau mus rau Intelligent Polymers

Cov keeb kwm ntawm cov khoom evolution ntawm OPU koob yog micro-scale chronicle uas nrhiav biocompatibility, txhua yam khoom, thiab cov txiaj ntsig kho mob. Los ntawm qhov nyuaj ntawm thawj- tiam stainless hlau koob, mus rau lub teeb yuag innovation ntawm titanium alloys, thiab mus rau kev tiv thaiv kab mob kiv puag ncig ntawm ib - lub sij hawm polymer koob, txhua yam khoom iteration yog ib tug systematic engineering teb rau qhov kawg kev sib tw ntawm "precisely sau tsis tshua muaj zog hlwb los ntawm cov ntaub so ntswg puas". Qhov kev tswj kav ntev thiab muaj kev txwv tsis pub siv cov koob stainless hlau: Kev kho mob - qib 316L stainless hlau, nrog nws lub zog zoo heev (lub zog tensile> 500 MPa), rigidity (elastic modulus 200 GPa), thiab mature sterilization kam rau ua, tau dhau los ua lub hauv paus ntawm reusable OPU koob. Nws lub siab rigidity ua kom lub koob ncej deflects tsawg kawg nkaus thaum nkag mus rau hauv lub paum phab ntsa thiab zes qe menyuam parenchyma, muab cov tswv yim zoo rau tus neeg teb xov tooj. Txawm li cas los xij, nyob rau hauv lub sijhawm ntawm kev mob siab rau kev xeeb tub zoo, nws cov kev txwv tau dhau los ua pov thawj. Lub siab elastic modulus ua rau cov tawv nqaij ntau dhau, uas tuaj yeem "tshem tawm" cov follicles tsis yog ncaj qha rau lawv thaum hla lub zes qe menyuam stroma, tshwj xeeb tshaj yog rau cov follicles nyob rau tom qab ntawm lub zes qe menyuam, feem ntau xav tau kev quab yuam ntau dua, yog li ua rau muaj kev pheej hmoo los ntshav. Lub teeb yuag kev tsim kho tshiab thiab kev lom zem kev sib raug zoo ntawm titanium alloy: TC4 titanium alloy (Ti-6Al{19}}4V) coj OPU koob rau hauv "lub teeb yuag, siab -precision" era. Nws cov txiaj ntsig tseem ceeb nyob hauv: 1) lub zog tshwj xeeb siab dua, tso cai rau cov phab ntsa nyias nyias thaum tuav tib lub zog sib tsoo - qhov no yog qhov tseem ceeb hauv kev nce cov kab hauv qab yam tsis hloov txoj kab uas hla. Piv txwv li, rau 17G koob, lub puab txoj kab uas hla ntawm titanium alloy koob (kwv yees 1.14 hli) tshaj li ntawm cov khoom stainless hlau coj (kwv yees 1.07 hli), uas txo cov dej tsis kam thaum cov kua follicular thiab oocyte -thaum lub cell complex dhau los ntawm 18%, cov neeg kho tshuab kev nyuaj siab. oocyte-kev sib tshuam ntawm tes; 2) biocompatibility zoo heev: lub spontaneous tsim ntawm ib tug tuab titanium oxide txheej ua rau ib tug zero corrosion tus nqi, tshem tawm tej zaum yuav cuam tshuam ntawm hlau ion leaching ntawm lub microenvironment ntawm lub follicular kua; 3) acoustic impedance zoo sib xws: qhov me me impedance sib txawv ntawm titanium alloy thiab tib neeg cov ntaub so ntswg ua rau pom tseeb ultrasound dluab, nce lub koob tip paub tus nqi kwv yees li 30%. Ib qho - lub sij hawm hloov pauv ntawm cov koob tshuaj kho mob polymer: Siab- cov khoom siv hluav taws xob zoo xws li polyetheretherketone (PEEK) thiab polycarbonate (PC) muaj cov txiaj ntsig tseem ceeb tsis nyob hauv cov hlau zoo tshaj hauv cov khoom siv kho tshuab, tab sis nyob rau hauv kev tsav los ntawm ob yam ntawm kev tiv thaiv kab mob thiab kev ua haujlwm txheem. Ib -lub sij hawm cov koob tshuaj polymer tshem tawm tag nrho cov ntoo khaub lig- kev pheej hmoo kis kab mob ntawm cov koob rov qab siv tau, tshem tawm qhov xav tau ntawm kev tu thiab ua kom tsis muaj menyuam, thiab txo cov nqi khiav haujlwm hauv tsev kho mob. Qhov tseem ceeb tshaj, cov ntaub ntawv polymer tuaj yeem ua tiav cov qauv tsim qauv tsim los ntawm kev txhaj tshuaj molding, xws li kev sib xyaw ncha cov cim thiab cov kua dej dynamics - optimized internal kab noj hniav geometries. Kev tsim kho tshiab hauv cov txheej txheem txheej txheej txheej txheej: Cov tuam txhab ua lag luam xws li Manners Medical tab tom siv cov txheej txheem hydrophilic thiab cov kab mob tua kab mob kom txo tau kev sib txhuam thaum siv, txo cov ntaub so ntswg adhesion, thiab txo cov kev pheej hmoo kis kab mob. Cov txheej no tseem tuaj yeem tiv thaiv oocytes los ntawm kev ntxhov siab thaum lub sij hawm aspiration, txhim kho cov ciaj sia taus. Composite coated OPU koob ua tau zoo heev puncture smoothness thiab kev tiv thaiv ntawm oocyte kev ncaj ncees. Kev tshawb nrhiav pem hauv ntej ntawm cov ntaub ntawv ntse teb: Cov koob OPU yav tom ntej yuav txais kev txhawb nqa- cov ntaub ntawv polymers thiab hydrogel cov ntaub ntawv sib xyaw, tuav kom nruj ntawm chav tsev kub kom du, thiab softening hauv zos nyob rau hauv lub cev kub los yog nyob rau hauv lub teeb stimulation tom qab nkag mus rau hauv lub zes qe menyuam kab noj hniav. Qhov kev tsim "rigidity- hloov pauv hloov" no ua rau txo qis cov neeg kho tshuab kev puas tsuaj rau zes qe menyuam thiab ua tiav cov haujlwm ultra- mos mos ua haujlwm tsawg. Nano-functionalized sab hauv phab ntsa biomimetic nano-coatings thiab cov kev hloov kho lom neeg ua haujlwm molecules yuav raug siv rau lub koob kab noj hniav, tsim los tiv thaiv adhesion interfaces, tso cai rau oocytes hla nrog xoom kev sib txhuam thiab xoom puas.