https://en.wikipedia.org/wiki/Microneedles

Kev lag luam tu tawv nqaij tau ntsib qhov tsis txaus ntseeg ntev: qhov feem pua ​​​​ntawm cov khoom xyaw zoo hauv cov tshuaj pleev ib ce thiab cov tshuaj pleev ib ce uas cov neeg siv khoom them tus nqi siab yog qhov tsawg heev, nrog tsawg heev absorbed thiab siv los ntawm daim tawv nqaij. Kev tshawb fawb tshawb fawb pom tau hais tias nyob rau hauv ib txwm siv cov xwm txheej, qhov transdermal nkag mus ntawm cov dej feem ntau - cov khoom xyaw soluble yog tsawg dua 1%, thaum lipid - cov khoom soluble tsis tshua muaj siab tshaj 5%. Qhov no txhais tau hais tias feem ntau ntawm cov khoom xyaw nquag tseem nyob ntawm daim tawv nqaij, thaum kawg ntxuav tawm los yog evaporated. Kev lag luam ntawm microneedling thev naus laus zis tau hloov pauv qhov kev xav hauv qab no ntawm "kev xa khoom tau zoo."

Qhov kev sib tw ntawm kev nqus ntawm cov khoom tu tawv nqaij ib txwm yog los ntawm daim tawv nqaij lub ntuj barrier -stratum corneum. Qhov no "cib-thiab-mortar" qauv, tsim los ntawm cov keratinocytes tuag thiab lipid matrix, tsuas yog 10 mus rau 20 micrometers tuab, tab sis nws zoo thaiv yuav luag txhua yam khoom uas muaj qhov hnyav molecular tshaj 500 daltons. Cov khoom xyaw nquag nquag hauv kev tu tawv nqaij niaj hnub- xws li hyaluronic acid, collagen peptides, vitamin C derivatives, thiab polypeptides- yog cov molecules loj heev. Microneedling tsim ib ntus microscopic channels los ntawm stratum corneum ntawm lub cev txhais tau tias, xa cov khoom siv tsis tau "giants" ncaj qha rau hauv daim tawv nqaij thiab txawm tias lub dermis, yog li nce transdermal nkag mus los ntawm tsawg dua 1% mus rau ntau dua 80%.

Qhov kev hloov pauv ntawm "kev ua tau zoo" no tau coj los ntawm kev hloov pauv ob zaug hauv cov khoom lag luam thiab cov neeg siv kev paub dhau los. Ntawm cov khoom sab, solublemicroneedlethaj ua rau thaj tau dhau los ua qhov nyiam tshiab hauv kev saib xyuas tawv nqaij zoo. Cov thaj ua rau thaj no encapsulate cov khoom xyaw nquag hauv cov koob los ntawm khov- ziab; thaum thov rau ntawm daim tawv nqaij, cov koob yaj hauv feeb, tso cov khoom xyaw ncaj qha rau ntawm qhov chaw. Piv nrog rau cov tshuaj pleev ib ce, microneedle thaj ua rau thaj yuav tsum tsis muaj cov tshuaj tua kab mob, cov khoom ua kom tuab, lossis cov emulsifiers - muab cov mis me me uas muaj txiaj ntsig zoo. Ua raws li qhov xav tau heev-tom qab "qhov muag thaj chaw microneedles," piv txwv li: ib thaj chaw uas muaj acetyl hexapeptide-8 muab cov txiaj ntsig tam sim ntawm kev txo qis ko taw piv rau kev siv cov ntshav qab zib nrog cov khoom sib xyaw tsis tu ncua rau ib hlis.

Ntawm cov neeg siv kev paub dhau los, microneedling tau tsav lub koob npe ntawm "ntawm-kev zoo nkauj hauv tsev." Yav dhau los, kev kho mob transdermal tsuas yog muaj nyob rau hauv cov chaw kho mob tshaj lij, tab sis tam sim no, ua tsaug rau zoo -tsim tsev- siv cov khoom siv microneedling, cov neeg siv khoom tuaj yeem ua cov kev kho mob no hauv lawv lub tsev. Cov tuam txhab lag luam tau tsim cov khoom lag luam raws li hom tawv nqaij sib txawv thiab xav tau, sib txawv ntawm rab koob ntev thiab cov khoom xyaw nquag: ultra- luv 150-micron koob ua ke nrog centella asiatica thiab ceramides rau cov tawv nqaij rhiab heev; nruab nrab- ntev 300-micron koob ua ke nrog retinol thiab collagen rau cov tawv nqaij laus; thiab yaj cov koob uas muaj salicylic acid rau pob txuv ntawm daim tawv nqaij. Qhov kev ua kom zoo dua qub, kev sib tw ua tau raws li cov neeg siv khoom xav tau ntau ntxiv rau cov kev daws teeb meem ntawm tus kheej.

Kev nyab xeeb ib txwm yog qhov tseem ceeb rau kev txiav txim siab ntawm -cov khoom siv microneedling hauv tsev. Cov npe nrov npe siv kev kho mob- qib stainless hlau lossis biodegradable polymers los tsim cov microneedles, ua kom tsis muaj menyuam thiab tsis yog- cov khoom tsis haum. Lub caij no, cov cuab yeej ntse microneedling tau nce ntxiv nrog lub siab sensors thiab qhov tob limiters los tiv thaiv cov ntaub so ntswg ntau dhau los ntawm kev siv zog dhau. Kev lag luam tseem nquag txhawb nqa cov txheej txheem kev lees paub los muab cov neeg siv khoom nrog cov lus qhia meej txog kev nyab xeeb.

Los ntawm "thov rau" mus rau "qhov tob tob," kev kho microneedling tau ua tiav qhov kev vam meej hauv kev xa cov tawv nqaij kom zoo. Nws ua kom ntseeg tau tias txhua qhov poob ntawm cov ntsiab lus tau siv tag nrho, tso cai rau txhua qhov kev kho mob ntawm daim tawv nqaij kom ncav cuag qhov tob tshaj plaws ntawm daim tawv nqaij. Qhov no tsis yog tsuas yog kev lag luam gimmick xwb, tab sis yog kev txhim kho thev naus laus zis tiag tiag.