Raws li cov kab mob vascular ntawm cov neeg mob lim ntshav dhau los ua nyuaj, cov koob tshuaj AVF tus qauv tau ua tsis tau raws li kev kho mob xav tau. Cov neeg tsim khoom yuav tsum tau txais cov qauv tsim los tsim cov khoom sib txawv tshwj xeeb rau cov neeg mob tshwj xeeb. Lawv yuav tsum ua kom zoo rau tag nrho cov txheej txheem, suav nrog lub koob lub ntsej muag zoo, cov qauv ntws ntws, thiab cov khoom siv xaiv, los daws cov teeb meem kev kho mob xws li kev sib tsoo nyuaj, cov ntshav tsis txaus, thiab cov hlab ntsha puas tsuaj.

Kev Tsim Nyog Tshwj Xeeb: Hais txog Cov Teeb Meem Ntawm Cov Kabmob Vascular Access

Rau cov neeg mob uas muaj tortuous lossis calcified cov hlab ntsha, cov chaw tsim tshuaj paus tau tsim lub kaum ntse ntse lub tswv yim (15℃- 45℃) ) kom txo tau cov puncture quab yuam los ntawm kev ua kom cov cheeb tsam sib cuag. Rau cov menyuam yaus lossis cov neeg uas muaj cov hlab ntsha nyias, cov lus qhia ntawm koob conical (nrog rau txoj kab uas hla ntawm 0.8mm) tau tsim los txo qhov kev pheej hmoo ntawm cov hlab ntsha tawg. Tus cwj pwm thev naus laus zis kho cov titanium alloy-coated koob taub rau tus neeg mob laus uas muaj vascular calcification. Los ntawm kev siv qhov hnav tsis kam ntawm titanium, lub neej kev pabcuam tau txuas ntxiv, thiab qhov chaw micro-arc oxidation kho tau txhim kho cov kev ua haujlwm tiv thaiv-thrombosis, nce tus neeg mob qhov kev ua tiav ntawm 60% mus rau 95%.

Ntau -Groove Flow Channels: Txhim kho Hemodynamics

Cov tshuaj ib txwm siv - qhov AVF koob yog qhov ua rau cov ntshav ntws tawm thiab vortex, uas ua rau cov ntshav liab puas thiab coagulation. Cov chaw tsim khoom siv tsib -axis laser txiav los tsim 2-4 kauv grooves nyob rau sab ntawm lub cev rab koob, ua rau laminar flow field. Piv txwv li, ib rab koob ob npaug rau tus neeg mob uas muaj lub xeev hypercoagulable muaj qhov dav ntawm 0.12mm thiab qhov tob ntawm 0.06mm, uas ua rau kom cov ntshav khiav ceev los ntawm 25% thiab txo qhov tshwm sim ntawm coagulation txheej xwm thaum lub sij hawm lim ntshav los ntawm 2 zaug hauv ib lub lis piam mus rau 0 zaug. Finite element tsom xam pom tau hais tias cov qauv zawj tuaj yeem ua kom zoo ntawm phab ntsa shear quab yuam los ntawm 15 dyn / cm² mus rau 25 dyn / cm², uas tsis tsuas yog txhawb nqa cov txheej txheem ntawm endothelial hlwb tab sis kuj inhibits platelet aggregation.

Cov Khoom Siv Kho Mob: Ua raws li qhov xav tau ntawm pawg tshwj xeeb

Rau cov neeg mob ua xua rau npib tsib xee, cov chaw tsim khoom siv cov tshuaj nitriding nto rau 316L stainless hlau, tsim cov txheej titanium nitride ceramic. Qhov no tsis tsuas yog tswj lub zog ntawm cov hlau tsis muaj steel, tab sis kuj tiv thaiv kev tso tawm ntawm cov nickel ions. Rau cov neeg mob uas xav tau ntev - lub sij hawm tso catheters, ib tug degradable magnesium alloy txheej koob tau tsim. Nws maj mam degrades hauv lub cev, zam vascular stenosis tom qab koob tshem tawm. Cov kev tsim kho tshiab no yuav tsum tau kuaj xyuas kev laus sai (70℃/ 2 lub lis piam los simulate 1 xyoos) thiab kev soj ntsuam kev nyab xeeb ntawm cov roj ntsha los xyuas kom muaj kev nyab xeeb ntawm kev cog qoob loo ntev -.

Clinical Collaborative Innovation Model

Cov tuam txhab ua lag luam tau tsim cov txheej txheem teb sai rau cov kev xav tau hauv chaw kho mob thiab tau koom tes nrog cov chaw lim ntshav kom ua tiav cov txheej txheem kaw -loop innovation txheej txheem ntawm "teeb ​​meem - daws - pov thawj." Piv txwv li, nyob rau hauv cov lus teb rau qhov teeb meem tsa los ntawm cov kws saib xyuas neeg mob hais tias "lub cev koob yog nquag zawv zawg", Manners Technology tsim los tiv thaiv -slip textures ntawm rab koob, ua rau muaj kev sib txhuam quab yuam los ntawm 40%; rau qhov mob taw tes ntawm "kev tso pa nyuaj," lawv tau tsim sab - lub qhov nqus pa, txo lub sijhawm tso tawm ntawm 3 feeb mus rau 30 vib nas this. Qhov kev sib koom tes tshiab no tau ua rau cov khoom lag luam rov ua dua los ntawm 18 lub hlis mus rau 6 lub hlis.

Xaus

Kev tsim kho ntawm AVF koob yog qhov cuam tshuam ncaj qha ntawm cov chaw tsim tshuaj paus kev pom zoo. Nws yuav tsum tau hloov cov kev xav tau ntawm tus neeg mob mus rau hauv cov kev daws teeb meem engineering. Tsuas yog los ntawm kev tsim kho tshiab tas mus li thiab rov hais dua tuaj yeem muab cov cuab yeej siv tau zoo dua thiab siv tau zoo dua rau cov neeg mob lim ntshav, ua kom paub tseeb tias "tus neeg mob- nyob nruab nrab" tus nqi kho mob.