Diagnostic Thiab Saib Xyuas Microneedles: Kev Sib Tw Tshuab Ntawm Silicon-Based Bionic Thiab Biolinq

Hauv kev soj ntsuam kev kho mob, microneedle technology yog tsav kev cuam tshuam kev hloov pauv hauv kev ua lag luam txuas ntxiv cov piam thaj (CGM). Silicon-Based Bionic thiab Biolinq sawv cev rau kev ua haujlwm thev naus laus zis los ntawm Tuam Tshoj thiab Tebchaws Meskas, raws li.

Innovation los ntawm Silicon-Based Bionic

Silicon-Based Bionic tus kheej-tsim Silicon-Based Dynamic CGM System txais kev siv thev naus laus zis thib ob ntawm cov piam thaj-sensor, ua rau 24-teev kev soj ntsuam tas li thiab lub sijhawm tiag tiag ntawm kev cog qoob loo hloov tau microneedles. Cov plaub hau-nyias microneedles no nkag mus rau hauv cov kua dej interstitial ntawm cov ntaub so ntswg subcutaneous nrog ze-pain tsis nkag. Tshaj li 14-hnub hnav khaub ncaws, cov neeg mob tau tso tawm los ntawm kev kuaj ntshav cov ntiv tes ua ntu zus, txo qhov mob hnyav dua thiab pheej hmoo kis mob. Cov cuab yeej ua tiav qhov ntsuas qhov yuam kev hauv qab 8.7%. Nrog rau kev kho mob-qib raug, calibration-dawb mob-dawb khiav hauj lwm, thiab real-time cov ntaub ntawv mus txog qhovtwg, nws lov lub sij hawm ntev monopoly ntawm lub ntiaj teb no giants tshaj core CGM technologies.

Technological Breakthrough los ntawm Biolinq

Thaum lub Cuaj Hlis 2025, Asmeskas-based Biolinq tau lees paub FDA pom zoo rau nws cov microneedle-electrode-array-raws li kev soj ntsuam ntshav qab zib tas li, Biolinq Shine. Tsim los ntawm ntau yam ywj pheej microneedle electrodes, tus tsim mitigates lub sij hawm-dependent teeb liab drift uas muaj nyob rau hauv cov pa electrochemical sensors, xa siab dua-precision glucose nyeem. Nws cov electrode array yog 20 npaug me dua li cov sib tw microneedles, xa cov kev ua tau zoo nyob ze thiab txo cov neeg mob tsis xis nyob. Biolinq's glucose sensor zam kev nkag mus rau qhov mob-sensitive dermal paj hlwb, txo qis qhov kev xav.

Kev sib piv

Ib txwm siv CGM sensors xws li Abbott's FreeStyle Libre series thiab Dexcom's G-Series cia siab rau ib leeg 5-6 hli koob-zoo li tus electrode ntxig rau hauv dermis kom ntes cov suab thaj los ntawm cov kua dej sib txuas. Qhov kev tsim no raug kev txom nyem los ntawm ob qhov teeb meem tseem ceeb: ua ntej, cov neeg mob 'kev puas siab puas ntsws aversion thiab mob lub cev tshwm sim los ntawm kev txhaj tshuaj ntev ntev; thib ob, ib leeg-point tsis ua hauj lwm muaj kev pheej hmoo - thaum lub electrode yog encapsulated los ntawm biofilm los yog raug teeb liab drift, tag nrho cov sensor yuav tsis ua hauj lwm. Los ntawm qhov sib piv, microneedle-array thev naus laus zis txo qhov ntev ntawm electrode mus rau 1 hli, tsuas yog ib feem tsib mus rau ib feem kaum ntawm cov khoom siv niaj hnub, txo qhov mob thiab tsis ua haujlwm.

UK Startup Sava

Thaum Lub Yim Hli 2025, UK lub tuam txhab kev noj qab haus huv-tech Sava tau kaw $ 19 lab Series-A puag ncig, nqa tag nrho cov nyiaj mus rau USD 32 lab, tsom rau kev tsim khoom loj ntawm nws cov microneedle-electrode-raws li kev soj ntsuam cov piam thaj tas li. Founded hauv 2019 los ntawm bioengineers Renato Circi thiab Rafael Michali los ntawm Imperial College London, Sava tab tom tsim kho lub biosensor uas muaj peev xwm tshawb pom lub sijhawm tiag tiag ntawm ntau yam subcutaneous biomarkers.

Suav Kev Tshawb Fawb Txog Kev Tshawb Fawb

Lub microneedle hnav tau tsim los ntawm Shenzhen Institutes of Advanced Technology enables ultrasound-pab tsis-invasive nruam kev soj ntsuam qabzib. Tus qauv ultrasound sojntsuam nyeem microneedle ntev variations, hloov cov piam thaj rau hauv quantifiable acoustic signals. Ib pab pawg sib koom ua ke coj los ntawm Associate Professor Yang Jian (University of South China), xibfwb Jiang Lelun thiab Yi Changqing (Sun Yat‑sen University), thiab xibfwb Hossam Haick (Technion-Israel Institute of Technology) tau tsim microneedle-based Continuous Drug/Biomarker Monitoring (MCBM) system, tsim kom muaj kev soj ntsuam xyuas cov sijhawm tsawg tsawg-hauv cov kua nplaum. hauv cov kua dej interstitial ntawm cov neeg mob ntshav qab zib.

Kev ua lag luam Outlook

Kev saib xyuas cov piam thaj yog ib qho lag luam uas muaj txiaj ntsig zoo, tsim ntau lab nyiaj daus las hauv cov nyiaj tau los txhua xyoo rau Abbott thiab Dexcom. Hauv 2024, ob lub tuam txhab ua ke CGM cov nyiaj tau los tshaj $ 10 billion (Abbott: USD 6.8 billion; Dexcom: USD 4.023 billion). Kev siv cov tshuab microneedle yuav tsum cuam tshuam qhov duopoly no, muab cov neeg mob yooj yim dua thiab raug nqi xyuas cov kev daws teeb meem.