Kev Tsis Pom Zoo Tom Qab Microneedling Thiab Lawv Mechanistic Analysis

https://en.wikipedia.org/wiki/Microneedles

Txhua lub tshuab kho mob muaj ob sab. Thaummicroneedle therapy qhia tau hais tias muaj txiaj ntsig zoo kawg nkaus hauv kev xa tshuaj tsis mob thiab kev tsom mus rau qhov tseeb, nws cov ntsiab lus tseem yog qhov cuam tshuam ntawm daim tawv nqaij. Nkag siab txog qhov muaj feem cuam tshuam tsis zoo tom qab kev kho mob microneedle thiab lawv cov txheej txheem physiological hauv qab yog qhov yuav tsum tau ua ua ntej rau kev nyab xeeb.

Cov kev phiv tshwm sim feem ntau yog cov lus teb ntawm daim tawv nqaij tam sim ntawd, suav nrog erythema, edema, thiab kub hnyiab. Cov tsos mob no tseem ceeb ua rau lub cev tiv thaiv kab mob. Thaum microneedles nkag mus rau hauv lub stratum corneum thiab epidermis, daim tawv nqaij pib ib tug mob inflammatory teb: capillary dilation ua rau lub zos redness, nce vascular permeability ua rau cov ntaub so ntswg exudation ua edema, thiab prostaglandins thiab bradykinin tso tawm los ntawm lub hlwb puas ua rau kub hnyiab thiab mob me. Feem ntau, cov tshuaj tiv thaiv no nce siab hauv 2 mus rau 4 teev tom qab kev kho mob thiab maj mam txo qis hauv 24 mus rau 48 teev. Txawm li cas los xij, rau cov tib neeg uas muaj kev cuam tshuam ntawm daim tawv nqaij nyob rau hauv qhov teeb meem -xws li cov neeg uas muaj rosacea, atopic dermatitis, los yog ntev - siv corticosteroids - cov lus teb inflammatory no yuav khaus ntau dua, kav ntev dua 72 teev.

Lwm qhov kev mob tshwm sim tseem ceeb yog dyschromia (pigmentation abnormalities). Ntawm cov neeg tawv nqaij tsaus nti, qhov tshwm sim ntawm post-inflammatory hyperpigmentation (PIH) tom qab microneedling tuaj yeem ncav cuag 10% mus rau 30%. Cov txheej txheem cuam tshuam nrog kev raug mob -induced activation ntawm tyrosinase nyob rau hauv melanocytes, txhawb kev nce melanin synthesis. Qhov kev pheej hmoo ntawm cov xim pigmentation nce siab heev thaum rab koob ntev tshaj 500 micrometers, kev kho mob ntau dhau, lossis tom qab- tiv thaiv tshav ntuj tsis txaus. Hauv qhov sib piv, cov tib neeg uas muaj cov tawv nqaij sib zog ua rau muaj kev cuam tshuam rau ib ntus hypopigmentation, uas feem ntau daws tau hauv lub lis piam.

Kev pheej hmoo kis kab mob yog qhov kev txhawj xeeb tseem ceeb hauv microneedling. Txawm hais tias tus txheej txheem yog me me, yog tias ua ntej- kev tua kab mob tsis tiav, intra- cov txheej txheem ua haujlwm raug ua txhaum cai, lossis tom qab- kev saib xyuas ua haujlwm tsis raug, cov kab mob xws liStaphylococcus aureus, Pseudomonas aeruginosa, lossis txawm tias tus kab mob herpes tuaj yeem siv qhov ua txhaum cai. Cov ntaub ntawv kho mob tau sau tseg cov ntaub ntawv ntawm lub ntsej muag cellulitis tshwm sim los ntawm kev tu vaj tse tsis txaus- siv microneedle rollers. Yog li ntawd, cov txheej txheem nruj aseptic thiab kev siv cov khoom siv pov tseg tsis yog cov lus qhia xaiv tab sis tsis yog - cov kab hauv qab kev nyab xeeb sib tham.

Tsis tas li ntawd, kev tsis haum tshuaj tshwm sim qee zaus. Microneedling qhib txoj hauv kev rau cov tshuaj los yog cov khoom siv tu tawv nqaij kom nkag mus tob rau hauv daim tawv nqaij, txhais tau hais tias cov khoom tsis muaj teeb meem thaum lub sij hawm sib cuag sab nraud tuaj yeem ua rau lub cev tiv thaiv kab mob thaum lawv nkag mus rau hauv dermis. Qhov kev pheej hmoo yog tshwj xeeb tshaj yog rau cov khoom uas muaj cov proteins, cov nroj tsuag rho tawm, lossis peptides. Kev kuaj daim tawv nqaij ua ntej kev kho mob raug pom zoo.

Nkag siab txog cov kev mob tshwm sim no tsis cuam tshuam tus nqi ntawm microneedling; es, nws tsim kom muaj kev cia siab rau cov kws kho mob thiab cov neeg siv tib yam nkaus. Tsuas yog nrog kev paub txog tag nrho cov kev pheej hmoo tuaj yeem ua tiav kev nyab xeeb thiab kev kho mob zoo.