Nyob rau hauv evolution ntawm microneedle technology, dissolvable microneedles sawv cev rau feem ntau xav txog pem hauv ntej tam sim no. Nws mus dhau ntawm ib qho kev ua haujlwm ntawm "txuas rau kev nkag mus," hloov cov microneedle lawv tus kheej mus rau hauv "cov tshuaj ntse ntse" uas tuaj yeem ua haujlwm hauv lub cev. Lub tswv yim tsim qauv ntawm kev sib txuas cov neeg ua haujlwm kho mob nrog cov neeg nqa khoom xa tuaj ua rau muaj kev hloov pauv ntsiag to hauv kev txhim kho tshuaj, kev kho mob zoo nkauj, thiab kev tswj kab mob ntev. Tsab ntawv xov xwm no yuav qhia txog cov ntaub ntawv tseem ceeb thiab kev txawj ntse tso tawm cov txheej txheem ntawm cov microneedles dissolvable, qhia lawv lub peev xwm loj heev li "cov chaw muag tshuaj me me uas cog tau."

Haum rau:Cov kws tshawb fawb pem hauv ntej hauv kev tsim tshuaj, cov kws tshaj lij hauv cov tshuaj kho dua tshiab, thiab cov pioneers nyob rau hauv ntev - tshawb nrhiav kev kho mob zoo nkauj.

Kab lus no yog qhov zoo tshaj plaws rau cov pab pawg hauv qab no los nyeem:

Cov kws tshawb fawb txog biomedical cov kws tshawb fawb thiab cov kws paub txog kev tsim tshuaj: tsom mus rau kev tsim cov tshuaj polymer tshiab-raws li kev xa cov tshuaj, nrog rau kev saib xyuas tshwj xeeb rau kev ruaj khov encapsulation thiab tswj kev tso tawm ntawm cov tshuaj loj molecule (proteins, peptides, nucleic acids).

Cov tshuaj tiv thaiv thiab cov kws tshawb nrhiav tshuaj tshiab: Nrhiav cov chaw xa tshuaj tiv thaiv tshiab uas tuaj yeem txhim kho lub cev tiv thaiv kab mob, ua kom yooj yim cov txheej txheem txhaj tshuaj, thiab ua tiav - tiv thaiv ntev.

Khoom R&D tus thawj coj hauv thaj chaw kho mob zoo nkauj: Tshawb nrhiav yuav ua li cas kom ua tiav ib qho kev kho mob uas muab kev tiv thaiv kev laus txuas ntxiv - rau ob peb lub lis piam lossis ntau lub hlis, rhuav tshem cov kev txwv tam sim ntawd.

Innovator nyob rau hauv cov qauv kev tswj kab mob ntev: Cia siab tias yuav tsim cov phiaj xwm kho mob tsis mob rau cov neeg mob uas xav tau ntev - noj tshuaj (xws li cov neeg mob ntshav qab zib), nrog kev siv ib zaug ib lim tiam lossis ib hlis ib zaug.

Kev siv scenario:Cov kev kho mob nyuaj uas yuav tsum tau muaj kev cuam tshuam tas mus li thiab cov txheej txheem tso tawm

Ntev -lub sij hawm analgesia thiab los tiv thaiv- cov nyhuv inflammatory: Tsim cov kab mob microneedle thaj ua rau thaj chaw uas tsis yog -steroidal anti- cov tshuaj tiv thaiv kab mob lossis cov tshuaj tsis muaj zog opioids rau cov neeg mob osteoarthritis thiab mob qis qis, muab cov tshuaj tua kab mob hauv zos rau ob peb hnub, tsis txhob muaj kev phom sij rau kev noj qab haus huv los yog kev quav yeeb quav tshuaj.

Tsis mob lwm txoj hauv kev rau cov tshuaj molecule loj: Tsim cov microneedle thaj ua rau cov tshuaj insulin los muab lwm txoj hauv kev rau cov neeg mob ntshav qab zib. Lub microneedle dissolves nyob rau hauv daim tawv nqaij, tso cov tshuaj insulin tsis tu ncua, ua raws li lub ntuj tso tawm, txhim kho kev ua raws cai.

Kev txhaj tshuaj tiv thaiv kab mob: Siv cov khoom siv hluav taws xob uas tsis tuaj yeem degradable los nqa cov tshuaj tiv thaiv antigens thiab adjuvants. Cov khoom siv polymer nws tus kheej tuaj yeem ua raws li lub cev tiv thaiv kab mob, thiab nws cov txheej txheem degradation tuaj yeem simulate cov kab mob ntawm cov kab mob, ua tiav cov tshuaj tiv thaiv kab mob los yog kev tso tawm tas mus li, yog li txhawb kev muaj zog thiab muaj zog ntau dua thiab kev tiv thaiv ntawm tes.

"Invisible implantation" rau kev kho mob zoo nkauj: Tsim cov microneedle dissolvable loaded nrog cov khoom xws li poly-L-lactic acid thiab collagen-stimulating peptides. Tom qab tso, microneedle maj mam degrades nyob rau hauv lub dermis, tsis tu ncua stimulating fibroblast regeneration ntawm collagen nyob rau hauv ib lub sij hawm ntawm ob peb lub hlis, ua tau raws li ib tug tseem ceeb transformation ntawm "tam sim ntawd filling" mus rau "ntev- lub sij hawm regeneration."

Kev kho mob thiab cov ntaub so ntswg engineering: Load yam loj hlob (xws li EGF, bFGF), tshuaj tua kab mob, los yog qia cell exosomes nyob rau hauv lub microneedles thiab siv lawv rau cov mob uas tsis yog{0}} kho qhov txhab. Cov microneedles tsis tsuas yog xa cov khoom nquag, tab sis kuj yog qhov chaw tsim tom qab degradation tuaj yeem coj cov hlwb kom nkag mus tau zoo, txhawb cov ntaub so ntswg rov qab.

Sib piv Advantage:Lub Platform-theem Leap los ntawm "Ib qho-lub sij hawm Stimulus" mus rau "Nruam Intelligent Intervention"

Piv nrog rau txheej txheej - hom microneedles lossis txoj kev xa tshuaj ib txwm siv, qhov zoo ntawm lub microneedle platform dissolvable yog nyob rau hauv nws cov kev tswj tau nyob rau hauv lub sij hawm dimension thiab nws cov functional integration.

Ib qho kev nce ntxiv hauv cov tshuaj - nqa lub peev xwm thiab hloov tau yooj yim ntawm cov ntawv siv tshuaj.

Qhov kev txwv ntawm txheej txheej - hom microneedles: Cov tshuaj tsuas yog txuas rau saum npoo, nrog lub peev xwm thauj khoom tsawg (feem ntau <1mg ib thaj), thiab lawv feem ntau yog cov khoom me me.

Kev tawg ntawm cov microneedles soluble: Cov tshuaj sib xyaw ua ke thoob plaws hauv matrix ntawm lub cev koob, thiab cov tshuaj thauj khoom tuaj yeem nce ntxiv los ntawm 1-2 qhov kev txiav txim siab, txaus los nqa cov tshuaj kho mob ntawm cov tshuaj loj molecule. Qhov tseem ceeb tshaj, nws tuaj yeem ua kom haum cov tshuaj, uas yog qhov tseem ceeb rau kev tiv thaiv kev ua haujlwm ntawm cov tshuaj lom neeg tsis ruaj khov xws li cov proteins, peptides, thiab mRNA, daws cov teeb meem kev lag luam ntawm qhov tsis ruaj khov thiab tsis ua haujlwm ntawm cov tshuaj no thaum khaws cia hauv cov tshuaj aqueous.

Qhov "programmable" thiab ntev - qhov ntev ntawm kev tso tawm kinetics.

Qhov no yog lub hauv paus ntawm nws "kev txawj ntse." Cov tshuaj tso tawm tsis tso siab rau qhov yooj yim diffusion, tab sis sib sib zog nqus ua ke nrog cov khoom degradation.

Qhov kev nthuav tawm nkhaus tuaj yeem tswj tau: Los ntawm kev xaiv cov polymers nrog qhov sib txawv degradation (xws li gelatin uas degrades li ob peb teev, thiab PLGA (copolymer ntawm poly (lactic acid)) thiab poly (glycolic acid)) uas degrades ntau lub lis piam mus rau ob peb lub hlis), thiab kho lawv qhov hnyav molecular, crystallinity, thiab copolymer ratio, tso tawm sai npaum li cas {0} xoom- xaj tas li- tus nqi tso tawm, mem tes tso tawm, lossis ncua kev tso tawm. Piv txwv li, nws muaj peev xwm tsim tau ib qho xwm txheej uas ib feem ntawm cov tshuaj tso tawm sai sai kom ncav cuag qhov kev kho mob concentration, ua raws li kev tso tawm qeeb kom tswj tau qhov concentration.

Kev ua tiav ntev - kev kho mob ntev: Nrog rau ib daim ntawv thov, kev tso tshuaj txuas ntxiv ob peb hnub, lis piam, lossis ntau hli tuaj yeem ua tiav. Qhov no ua kom yooj yim rau kev xav tau ntau yam kev tswj hwm txhua hnub (xws li kev txhaj tshuaj insulin) rau ib lub lim tiam lossis txhua hli hloov pauv, uas sawv cev rau kev txhim kho kev hloov pauv hauv cov neeg mob kev paub.

Biocompatibility thiab "tsis muaj residue" kev nyab xeeb feature.

Cov ntaub ntawv siv hauv cov microneedles dissolvable yog txhua yam biodegradable thiab biocompatible, xws li hyaluronic acid, chondroitin sulfate, polylactic acid, gelatin, thiab lwm yam. Tom qab ua tiav lawv lub luag haujlwm ntawm kev xa tshuaj, cov ntaub ntawv no nws thiaj li yuav metabolized rau hauv dej, carbon dioxide, los yog amino acids thiab lwm yam khoom uas twb muaj lawm nyob rau hauv lub cev tsis muaj hydrolysis los yog enzymatic tag nrho. tsis yog -degradable residues. Qhov no pab daws cov teeb meem uas cov tshuaj cog qoob loo yuav xav tau kev phais tshem tawm, kom ntseeg tau tias muaj kev nyab xeeb ntev ntev -.

Lub peev xwm ntawm ntau- kev sib koom ua ke thiab kev tso tawm teb.

Lub soluble microneedle platform muab lub hauv paus rau kev koom ua ke ntau txoj haujlwm:

Kev tso tawm ntau yam tshuaj: Cov tshuaj sib txawv tuaj yeem thauj khoom hauv cov microneedles sib txawv ntawm ib qho array lossis hauv cov txheej txheem sib txawv ntawm tib lub microneedle, ua tiav kev kho "cocktail" rau cov tshuaj kho mob thiab cov koob tshuaj meej meej.

Ib puag ncig- teb tawm: Los ntawm kev tsim cov ntaub ntawv ntse, kev degradation thiab tshuaj tso tawm ntawm microneedles tuaj yeem teb rau cov cim ntawm lub cev, xws li kev hloov pauv hauv pH ntawm qhov chaw mob, qhov concentration lossis kev ua haujlwm ntawm cov enzymes tshwj xeeb, lossis qib oxygen reactive, ua rau "ntawm- xav tau" kev tswj hwm tshuaj, ua kom muaj kev nyab xeeb thiab txhim khu kev qha.

Nyob rau hauv cov ntsiab lus, lub soluble microneedle technology cim ib tug zoo hloov nyob rau hauv microneedles los ntawm tsuas yog ib tug "tawv" mus rau ib tug "platform." Nws tsis yog tsuas yog "tus yuam sij" qhib qhov rooj ntawm daim tawv nqaij; xwb, nws yog nws tus kheej ib tug zoo-tsim thiab nws tus kheej- ua haujlwm "micro pharmaceutical factory." Nws hloov cov txheej txheem xa tshuaj los ntawm kev cuam tshuam sab nraud, cuam tshuam tsis tu ncua mus rau endogenous, nruam, thiab ntse physiological tswj. Rau kev tshawb fawb txog tshuaj thiab kev kho mob siab heev, kev paub txog kev siv tshuab microneedle soluble txhais tau hais tias muaj tus yuam sij kub los qhib lub sijhawm ntev - kav ntev, tsis mob, thiab kev txawj ntse ntawm tus kheej kev kho mob. Nws tus nqi mus deb dhau ntawm daim ntawv noj tshuaj tshiab; nws sawv cev rau kev kho mob lub tswv yim taw qhia rau yav tom ntej.