Tshaj li kev kuaj mob - Lub luag haujlwm hloov pauv ntawm pob txha pob txha Biopsy koob hauv kev kho mob saib xyuas thiab tshawb fawb

https://www.chamfondbiotech.com/4-types-of-pob txha-marrow-biopsy-needles/

Tus nqi ntawm covpob txha hlwb biopsy koobncua deb dhau nws lub luag haujlwm txiav txim siab hauv kev kuaj mob thawj zaug. Nyob nruab nrab ntawm cov nthwv dej ntawm cov tshuaj niaj hnub precision, nws tau xav tias muaj kev ua haujlwm tseem ceeb ntxiv los ua cov cuab yeej tseem ceeb thoob plaws tag nrho cov kev kho mob thiab tus neeg tsav tsheb ntawm kev nce qib hauv kev tshawb fawb kho mob.

Nyob rau hauv cov nqe lus ntawm kev saib xyuas kev ua tau zoo, cov pob txha pob txha biopsy sawv ua "tus qauv kub" rau kev ntsuam xyuas cov lus teb hauv hematologic malignancies. Rau cov neeg mob leukemia uas tau txais kev kho mob los yog kev kho mob, kev ntsuam xyuas cov pob txha pob txha yog tib txoj kev txhim khu kev qha los txiav txim seb puas Ua tiav Kev Tso Cai (CR) tau ua tiav. Kev rov qab ntawm cov ntshav peripheral suav tuaj yeem tsuas yog sab nraud xwb; Nws tsuas yog los ntawm kev nkag mus rau hauv cov pob txha nrog rab koob biopsy kom paub tseeb tias qhov tawg feem pua ​​​​ntawm qis dua 5%-thiab tsis muaj kab mob extramedullary tshwm sim- qhov tseeb CR tuaj yeem tshaj tawm. Rau cov neeg mob tau txais CAR-T cell therapy lossis hematopoietic stem cell transplantation, cov pob txha pob txha biopsy koob tau dhau los ua ib qho cuab yeej muaj zog rau kev kuaj xyuas Kab Mob Tsawg Tsawg (MRD). Los ntawm kev siv cov txheej txheem siab -rhiab heev xws li ntws cytometry lossis PCR ntawm kev kuaj ntshav biopsy, cov kws tshawb nrhiav tuaj yeem txheeb xyuas cov qog nqaij hlav seem txawm tias muaj zaus tsawg li ib ntawm kaum txhiab lossis ib puas txhiab, yog li qhia cov kev cuam tshuam tom ntej los tiv thaiv kev rov qab los.

Nyob rau hauv lub cheeb tsam ntawm cov tshuaj tiv thaiv mechanisms thiab kev tsim tshuaj tshiab, cov pob txha pob txha biopsy koob muab irreplaceable "nyob pov thawj." Cov kev sim tshuaj feem ntau xav tau kev tshuaj xyuas ua ke ntawm cov neeg mob pob txha cov qauv sau ua ntej thiab tom qab kho. Los ntawm kev sib piv cov kev tshawb fawb, cov kws tshawb fawb tuaj yeem pom qhov kev hloov pauv ntawm cov noob hloov pauv nyob rau hauv cov tshuaj siab -piv txwv li, txheeb xyuas qhov chaw hloov pauv tshiab los yog nthuav tawm seb cov qog microenvironment tau hloov kho li cas (xws li kev nce hauv cov tshuaj tiv thaiv kab mob). Cov ntaub ntawv no yog qhov tseem ceeb rau kev nkag siab txog cov tshuaj siv tshuaj ntawm kev ua, kwv yees kev tiv thaiv, thiab tsim cov tshuaj tom ntej - tiam tshiab los kov yeej nws. Piv txwv li, nyob rau hauv kev txhim kho cov phiaj xwm kev kho mob rau FLT3-mutated mob myeloid leukemia, serial pob txha pob txha biopsy cov ntaub ntawv ua lub hauv paus tseem ceeb rau kev ua kom pom cov tshuaj ua tau zoo thiab elucidating kuj mechanisms.

Tsis tas li ntawd, kev siv cov koob txhaj tshuaj pob txha pob txha tau nthuav dav rau hauv txoj kev tshawb fawb ntawm cov kab mob uas tsis yog -malignant. Hauv kev tshawb fawb ntawm aplastic anemia, core biopsy cov qauv yog siv los ntsuas cov pob txha pob txha microenvironment, suav nrog qhov ntau thiab kev ua haujlwm ntawm mesenchymal qia hlwb, vascular ntom, thiab kev hloov pauv hauv extracellular matrix. Cov kev tshawb pom no pab nthuav tawm cov hauv paus hauv paus ua rau cov pob txha tsis ua haujlwm thiab muab kev nkag siab rau kev tsim kho tshiab los txhawb hematopoietic reconstitution. Txawm hais tias nyob rau hauv cov kab mob metabolic (xws li hlau ntau dhau) thiab cov kab mob sib kis (xws li cov kab mob sib kis), cov kab mob qog nqaij hlav tuaj yeem ua rau qee zaum tau txais txiaj ntsig tsis tau xav txog tseem ceeb heev rau kev kuaj mob. Nrog rau kev nce qib ntawm kev txiav-ntug thev naus laus zis zoo li ib leeg- cell sequencing thiab spatial transcriptomics, cov qauv muaj txiaj ntsig tau txais los ntawm cov pob txha pob txha yuav txuas ntxiv nthuav tawm cov kev nkag siab tob tob, tsis tu ncua thawb cov ciam teb ntawm tib neeg kev nkag siab txog lub hematopoietic system.