Inoculation koob subcutaneously los yog intramuscular txhaj koob

Kev txhaj tshuaj sib txawv yog txawv:

Qhov ncauj: tshuaj tiv thaiv kab mob polio (cov tshuaj qab zib), rotavirus

Intradermal txhaj: BCG txhaj tshuaj

Kev txhaj tshuaj subcutaneous: tshuaj tiv thaiv kab mob RUBELLA, tshuaj tiv thaiv kab mob, tshuaj tiv thaiv kab mob MUMPS, tshuaj tiv thaiv kab mob meningitis, tshuaj tiv thaiv JE, tshuaj tiv thaiv kab mob HEPATITIS, tshuaj tiv thaiv VARICella, tshuaj tiv thaiv MUMPS, tshuaj tiv thaiv kab mob, tshuaj tiv thaiv kab mob, thiab lwm yam.

Intramuscular txhaj (tseem hu ua intramuscular txhaj): DPT, diphtheria, kab mob siab B, tshuaj tiv thaiv kab mob vwm, tshuaj tiv thaiv kab mob khaub thuas

Lwm tus siv ntau txoj hauv kev nyob ntawm qhov xwm txheej: piv txwv li, qee cov tshuaj tiv thaiv kab mob khaub thuas tau muab tshuaj intramuscular, subcutaneous lossis ob qho tib si. Inactivated influenza vaccines nyob rau hauv txoj kev loj hlob yog muab rau subcutaneously (los yog intramuscularly) los yog intranasally. Thiab HIB feem ntau yog txhaj tshuaj intramuscular, qee qhov xwm txheej tshwj xeeb (xws li kab mob hemorrhagic txhaj tshuaj subcutaneously).

Tab sis cov tshuaj tiv thaiv subcutaneous yog qhov ntau dua.

Qhov no tsis muaj dab tsi cuam tshuam nrog cov tshuaj tiv thaiv Class I thiab Class II, cov tshuaj tiv thaiv kab mob rabies yog intramuscular zoo li cov tshuaj tiv thaiv Class I; Measles yog ib hom tshuaj tiv thaiv Class I tab sis koj tseem yuav tsum tau muab nws subcutaneously.

2. Tus kab mob no kis rau cov paj hlwb li cas

Yog li cas tus kab mob coronavirus tshiab kis rau cov paj hlwb? Lub ACE2 receptor yog paub tias yog ib qho chaw sib koom tes rau tus kab mob coronavirus tshiab, tab sis nws cov lus qhia mRNA kuj qis hauv lub paj hlwb. Pab neeg no pom cov theem qis ntawm ACE2 qhia hauv tag nrho 31 lub xov tooj ntawm tes los ntawm kev sib txuas ib leeg.

Txawm li cas los xij, ACE2 protein qhia ntau dua nyob rau hauv ntau lub paj hlwb, xws li MAP2- cov paj hlwb zoo uas qhia txog qib siab. Cov txiaj ntsig no tau qhia tias tsis muaj kev sib raug zoo ntawm ACE2 transcription qib thiab qib qhia protein.

Yog li, nws muaj feem ntau tias tus kab mob tseem cuam tshuam cov paj hlwb los ntawm ACE2 receptors. Txhawm rau ua kom pom qhov kev sim, pab pawg tau rho tawm cov kua dej cerebrospinal (CSF) los ntawm COVID-19 cov neeg mob uas muaj cov tshuaj tiv thaiv kab mob nruab nrab thiab incubated nrog organoids, pom tias nws txo cov kab mob organoid los ntawm COVID-19.

Txhawm rau tshawb xyuas ntxiv txog qhov cuam tshuam ntawm SARS-CoV-2 ntawm CNS hauv vivo, pab pawg tau tig mus rau humanized ACE2 transgenic nas thiab pom los ntawm immunofluorescence uas SARS-CoV-2 tau nthuav dav hauv ntau lub hlwb hauv 7 hnub. tom qab kis kab mob (Daim duab 2A-E).

Los ntawm kev qhia ncaj qha ACE2 receptors nyob rau hauv lub hlwb thiab kis tus kabmob coronavirus nrog AAV-HAEC2, pab pawg pom tias mob hlwb ib leeg ua rau poob phaus thiab tuag hauv cov nas, txawm tias qhov koob tshuaj tsuas yog ib puas feem pua ​​​​ntawm cov mob ntsws (Daim duab 2H-J ).

Cov kws sau ntawv tau taw qhia tias cov paj hlwb kis tus kabmob tshiab yog ib qho tseem ceeb ntawm kev tuag los ntawm tus kabmob tshiab. Cov kev tshawb fawb yav dhau los tau pom tias qhov tshwj xeeb tshaj tawm ntawm ORF3a protein nyob rau hauv Drosophila hlwb txhawb neuroapoptosis, neuroinflammation, thiab tuag, tab sis cov pro-apoptotic protein NSP1 tsis muaj zoo li neurotoxicity. Yog li ntawd, nws tseem yog ib qho teeb meem tseem ceeb nyob rau hauv pem hauv ntej ntawm peb los kawm txog cov txheej txheem molecular ntawm cov kab mob hauv lub paj hlwb uas tshwm sim los ntawm COVID-19. Pab neeg tus qauv ntawm kab mob organoid thiab nas hlwb qhia txog kev ua tau zoo rau lo lus nug no.

Yog tias koj muaj lus nug, thov hu rau peb. Peb lub tuam txhab tuaj yeem tsim ntau yam koob txhaj tshuaj, koob tshuaj kho mob, koob txhaj tshuaj, koob tshuaj hypodermic, koob txhaj tshuaj, koob tshuaj tiv thaiv kab mob, koob txhaj tshuaj, koob txhaj tshuaj, koob txhaj tshuaj, koob xaum koob, koob ovum khaws koob, koob txhaj tshuaj, thiab lwm yam Yog tias koj xav tau kev kho koob cov khoom, thov hu rau peb. Peb tos ntsoov rau koj qhov kev nug! Qhov zoo ntawm cov khoom tsim nyob rau hauv peb lub Hoobkas yuav txaus siab rau koj!

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